Development and optimized pairing of mouse monoclonal antibodies for detecting hemagglutinin in novel H7 subtype influenza viruses
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15 صفحه اولEvaluation of replication and pathogenicity of avian influenza a H7 subtype viruses in a mouse model.
Avian influenza A H7 subtype viruses pose a significant threat to human health because of their ability to transmit directly from domestic poultry to humans and to cause disease and, sometimes, death. Although it is important to develop vaccines against viruses of this subtype, very limited information is available on the immune response and pathogenesis of H7 viruses in animal models such as m...
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BACKGROUND AND PURPOSE The conventional method used for subtyping of antibodies against avian influenza viruses is hemagglutination inhibition (HI) test. However, the HI test is laborious and requires preparation of antigen from viable viruses that might be hazardous. The aim of this study was to develop a blocking enzyme-linked immunosorbent assay (B-ELISA) for detection of antibody of avian i...
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The family Herpesviridae is a large, diverse family of double-stranded enveloped DNA viruses. Herpes B virus (BV) and Cercopithecine herpesvirus 2 (CeHV-2) are simian herpesvi-ruses. Like herpes simplex virus 1 (HSV-1), they belong to the a-herpesvirus subfamily. interest in BV infections results from the observation that zoonotic infections often result in death of humans, whereas infection of...
متن کاملComputational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus
An avian-origin influenza H7N9 virus epidemic occurred in China in 2013-2014, in which >422 infected people suffered from pneumonia, respiratory distress syndrome and septic shock. H7N9 viruses belong to the H7 subtype of avian-origin influenza viruses (AIV-H7). Hemagglutinin (HA) is a vital membrane protein of AIV that has an important role in host recognition and infection. The epitopes of HA...
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ژورنال
عنوان ژورنال: Science China Life Sciences
سال: 2019
ISSN: 1674-7305,1869-1889
DOI: 10.1007/s11427-018-9486-0